It was observed that the distribution of cocaine in tissues had differed depending on the preservation conditions. Only benzoylecgonine was detected both in tissues and their formalin solution. In specimens stored at -20 degrees C, cocaine and its metabolite benzoylecgonine were detected in the tissues. Serum samples were taken immediately after poisoning and studied as well. Organs of the first group were preserved and stored at -20 degrees C without adding formalin, whereas the organs of the second group were preserved and stored in formalin solution at room temperature (25 degrees C). Tissues (liver, lung, kidney, brain) taken from rats, which have been poisoned acutely with cocaine, were preserved in two different conditions, analyzed by GC-MS, and then compared. The stability of drugs in formalin solution is an important factor in forensic investigation. Hilal, Ahmet Dağlioğlu, Nebīle Battal, Dīlek Yener, Fadīle Dağlioğlu, Kenan Detection of cocaine and benzoylecgonine in formalin fixed rat tissues.
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